Chmielnicka J, Bem E M, Kaszubski P
Environ Res. 1983 Aug;31(2):273-8. doi: 10.1016/0013-9351(83)90004-x.
Three groups of rats were given sodium selenite (Se), sodium selenite and cadmium chloride (Se + Cd), or sodium selenite, cadmium chloride, and mercuric chloride (Se + Cd + Hg), respectively. All animals received subcutaneous doses of 115CdCl2 (0.3 mg Cd/kg) every other day for a fortnight. Mercuric chloride was administered intravenously at doses of 0.5 mg Hg/kg every other day and Na2 75SeO3 intragastrically at doses of 0.1 mg Se/kg every other day for 2 weeks. The whole-body retention of selenium was slightly elevated by cadmium and increased threefold by cadmium with mercury (mainly blood, liver, and kidneys). Cadmium did not affect subcellular levels of selenium in the kidneys and slightly increased the selenium content in the soluble fraction of the liver. On the other hand, combined administration of mercury and cadmium induced a significant elevation of the selenium content in all subcellular fraction of the kidneys and in the nuclear and mitochondrial fractions of the liver. In all animal groups selenium was bound in the soluble fractions of both the liver and kidneys by high-molecular-weight proteins.
将三组大鼠分别给予亚硒酸钠（Se）、亚硒酸钠和氯化镉（Se + Cd）或亚硒酸钠、氯化镉和氯化汞（Se + Cd + Hg）。所有动物每隔一天皮下注射115CdCl2（0.3 mg Cd/kg），持续两周。每隔一天静脉注射0.5 mg Hg/kg的氯化汞，每隔一天经胃给予0.1 mg Se/kg的Na2 75SeO3，持续2周。镉使硒在全身的潴留量略有升高，镉与汞共同作用时（主要在血液、肝脏和肾脏中），硒的潴留量增加了两倍。镉不影响肾脏中硒的亚细胞水平，且使肝脏可溶性部分中的硒含量略有增加。另一方面，汞和镉联合给药导致肾脏所有亚细胞部分以及肝脏的核和线粒体部分中的硒含量显著升高。在所有动物组中，硒在肝脏和肾脏的可溶性部分中均与高分子量蛋白质结合。
