Wood S, Rom W N, White G L, Logan D C
J Occup Med. 1983 Jul;25(7):527-30.
Pentachlorophenol (PCP) is a pesticide commonly used as a wood preservative. Although exposure has been well controlled in large chemical manufacturing plants, over-exposures have recently becomes a concern at smaller facilities. Five cases of PCP poisoning, including two fatalities, occurred in two small wood preservative plants. All cases presented with fever, including severe hyperpyrexia in two; an increased anion gap and renal insufficiency were noted in two others. PCP may uncouple oxidative phosphorylation, resulting in a poisoning syndrome characterized by hyperpyrexia, diaphoresis, tachycardia, tachypnea, abdominal pain, nausea, and even death.
五氯苯酚（PCP）是一种常用作木材防腐剂的杀虫剂。尽管在大型化工生产厂中接触已得到很好的控制，但最近在较小的设施中过度接触已成为一个问题。在两家小型木材防腐厂发生了5起五氯苯酚中毒事件，其中2人死亡。所有病例均有发热表现，其中2例为严重高热；另外2例出现阴离子间隙增加和肾功能不全。五氯苯酚可能会使氧化磷酸化解偶联，导致以高热、出汗、心动过速、呼吸急促、腹痛、恶心甚至死亡为特征的中毒综合征。
