Pandey G N, Baker J, Chang S, Davis J M
Clin Pharmacol Ther. 1978 Sep;24(3):343-9. doi: 10.1002/cpt1978243343.
Two incubation procedures were used for the determination, in vitro, of the steady-state Li+ ratio between red cells and external media. The Li+ ratio in vitro determined prior to Li+ therapy correlates significantly with the subsequent ratio in vivo between red cells and plasma in patients treated with Li+. The Li+ ratio determined in vitro in patients during Li+ therapy was significantly higher than the value determined during the pretreatment, drug-free period that correlated significantly with Li+ ratios in vivo. The in vitro procedure used thus could be applied in the prediction of the in vivo Li+ ratio, and possibly of the response to Li+, in patients before treatment is begun. It also could be used for studies on abnormalities and on the genetics of Li+ transport in affective illness.
采用两种孵育程序在体外测定红细胞与外部介质之间的稳态锂离子比率。在锂治疗前测定的体外锂离子比率与接受锂治疗患者随后体内红细胞与血浆之间的比率显著相关。在锂治疗期间患者体外测定的锂离子比率显著高于治疗前无药物期测定的值，而该值与体内锂离子比率显著相关。因此，所采用的体外程序可用于在开始治疗前预测患者体内的锂离子比率，以及可能对锂的反应。它还可用于研究情感性疾病中锂转运的异常和遗传学。
