Lundy J, Welch J P, Berman M
J Surg Oncol. 1983 Sep;24(1):11-4. doi: 10.1002/jso.2930240104.
A retrospective chart review was undertaken on all Hartford Hospital Tumor Registry patients under age 40 with a diagnosed adenocarcinoma of the colon or rectum between the years 1955 and 1980. Of the 45 patients who could be accurately staged by the Dukes classification, only about one-third had disease localized to the bowel. No unique histological pattern was observed. An excess of multiple primary tumors was observed (13%). Stage of disease at the time of presentation, rather than histology, was the most important prognostic factor in this study. Carcinoma of the rectum in our series had a 5-year survival rate of 8%. This group of young patients should be managed with aggressive multimodal therapy.
对1955年至1980年间哈特福德医院肿瘤登记处诊断为结肠或直肠癌的所有40岁以下患者进行了回顾性病历审查。在45例可通过杜克分类法准确分期的患者中，只有约三分之一的疾病局限于肠道。未观察到独特的组织学模式。观察到多原发性肿瘤过多（13%）。在本研究中，就诊时的疾病分期而非组织学是最重要的预后因素。我们系列中的直肠癌患者5年生存率为8%。这组年轻患者应采用积极的多模式治疗。
