Aronson J F, McClaskey J W, Cristofalo V J
Mech Ageing Dev. 1983 Mar-Apr;21(3-4):229-44. doi: 10.1016/0047-6374(83)90043-x.
The loosely associated lung mesenchymal cell found between the ducts of the 3-to 4-month fetus is considered to be the probable progenitor of lung fibroblast cultures and of alveolar interstitial cells. A possible stage- and tissue-specific property of this cell type, the reduction of cortisone to cortisol, is defined and its activity studied in a variety of cell lines. Fibroblast lines derived from both fetal and adult lung had about ten times the cortisone-reducing activity of corresponding skin fibroblast lines. This relatively high activity was also characteristic of cell lines established by cloning the initial fetal lung digest. Lines established from developmentally related esophagus and from trachea had less activity than corresponding lung fibroblasts. A high level of cortisone-reducing activity was maintained in four serially passaged lung fibroblast lines for at least 85% of the proliferative life span and a second cell property, the enhancement of this activity by pretreatment with cortisol, was also maintained in three of the four lines.
在3至4个月大胎儿的导管之间发现的松散关联的肺间充质细胞被认为可能是肺成纤维细胞培养物和肺泡间质细胞的祖细胞。定义了这种细胞类型可能的阶段和组织特异性特性，即将可的松还原为皮质醇，并在多种细胞系中研究了其活性。来自胎儿和成人肺的成纤维细胞系的可的松还原活性约为相应皮肤成纤维细胞系的十倍。这种相对较高的活性也是通过克隆最初的胎儿肺消化物建立的细胞系的特征。从发育相关的食管和气管建立的细胞系的活性低于相应的肺成纤维细胞。在四个连续传代的肺成纤维细胞系中，至少在增殖寿命的85% 内保持了高水平的可的松还原活性，并且四个系中的三个系还保持了第二个细胞特性，即通过用皮质醇预处理来增强这种活性。
