Tanswell A K, Smith B T
Biol Neonate. 1980;37(1-2):32-8. doi: 10.1159/000241253.
Growth and conversion of cortisone to cortisol by human fetal lung fibroblasts in monolayer cell culture have been found to be sensitive to steady-state oxygen concentrations or to acute oxidant stresses. Oxygen-dependent differences are significantly modified by pre-incubation with cortisol. We speculate that cortisol may have an oxygen-protective role, and that the induction of increased conversion of cortisone to cortisol with an increase in oxygen tension, such at that observed at delivery, may be of significance in the prematurely born infant with the respiratory distress syndrome.
在单层细胞培养中，人胎儿肺成纤维细胞将可的松转化为皮质醇的过程以及细胞生长已被发现对稳态氧浓度或急性氧化应激敏感。预先用皮质醇孵育可显著改变氧依赖性差异。我们推测，皮质醇可能具有氧保护作用，并且随着氧张力增加（如在分娩时观察到的那样），可的松向皮质醇转化增加的诱导作用可能对患有呼吸窘迫综合征的早产婴儿具有重要意义。
