Laskarzewski P M, Morrison J A, Gutai J, Khoury P R, Glueck C J
Pediatr Res. 1983 Aug;17(8):689-98. doi: 10.1203/00006450-198308000-00018.
In a 1-year longitudinal study of 19 adolescent boys, our major aim was to assess whether, and to what degree, testosterone, estradiol, Quetelet index, and their interactions related to concentrations of high and low density lipoprotein cholesterol (HDLC, LDLC). During the 1-year followup, mean HDLC and estradiol levels fell and triglycerides, LDLC, Quetelet index, and testosterone levels rose. For large decreases in estradiol, increases in testosterone were associated with decreases in HDLC. These decreases in HDLC were moderated by small decreases in Quetelet index. For boys with small decreases in estradiol, as the changes in testosterone increased, the change in HDLC varied from an increase to a decrease, except in those boys who also had a small decrease in Quetelet index, for whom the change in HDLC was positive. The greatest increases in LDLC were observed in boys having the largest increase in Quetelet index and a small decrease in estradiol; however, as the decrease in estradiol became large, the positive association of Quetelet with LDLC was moderated or nullified. For boys having large decreases in estradiol, the LDLC/HDLC ratio changed from small increments to substantial decrements as testosterone increased. As the decreases in estradiol became smaller, increases in the change of testosterone moderated the decreases in the LDLC/HDLC ratio, and large increases in Quetelet index tended to diminish this moderation. As the change in testosterone increased, the change in triglyceride increased, unless the decrease in estradiol was small. The overall pattern of change of HDLC and LDLC during sexual maturation in boys can be associated with changes in testosterone, estradiol, and Quetelet index.
在一项针对19名青春期男孩的为期1年的纵向研究中，我们的主要目的是评估睾酮、雌二醇、体重指数及其相互作用是否以及在何种程度上与高密度脂蛋白胆固醇（HDLC）和低密度脂蛋白胆固醇（LDLC）的浓度相关。在1年的随访期间，平均HDLC和雌二醇水平下降，而甘油三酯、LDLC、体重指数和睾酮水平上升。对于雌二醇大幅下降的情况，睾酮升高与HDLC下降相关。体重指数的小幅下降缓和了HDLC的这些下降。对于雌二醇小幅下降的男孩，随着睾酮变化增加，HDLC的变化从增加变为下降，但体重指数也有小幅下降的男孩除外，他们的HDLC变化为正向。体重指数增加最大且雌二醇有小幅下降的男孩中观察到LDLC增加最多；然而，随着雌二醇下降幅度变大，体重指数与LDLC的正相关关系减弱或消失。对于雌二醇大幅下降的男孩，随着睾酮增加，LDLC/HDLC比值从小幅增加变为大幅下降。随着雌二醇下降幅度变小，睾酮变化增加缓和了LDLC/HDLC比值的下降，而体重指数的大幅增加往往会削弱这种缓和作用。随着睾酮变化增加，甘油三酯变化增加，除非雌二醇下降幅度较小。男孩性成熟过程中HDLC和LDLC的总体变化模式可能与睾酮、雌二醇和体重指数的变化有关。
