Nylén P, Bäckström B, Hagman M, Johnson A C, Collins V P, Höglund G
Department of Neuromedicine, National Institute of Occupational Health, Solna, Sweden.
Arch Toxicol. 1993;67(6):435-41. doi: 10.1007/BF01977406.
Albino (Sprague-Dawley) and pigmented (Norwegian Brown) male rats were exposed to 2,5-hexanediol (H; 1%) in their drinking water for 5 or 8 weeks, respectively. Half of the rats of each strain were housed in light (average 30 cd/cm2 inside cage, 12 h/day); the other half was kept in constant darkness. Control groups were studied in parallel under identical conditions but without H. Electrophysiological recordings were made 2-5 days and 13 weeks after the end of the exposure to H. Alterations in the visual system, as measured by electroretinography and visual evoked response, were found in groups of albino rats exposed to H and/or light. The pupillary diameter was enlarged in the albino group exposed to both H and light. Among the pigmented rats, alterations were recorded only in the visual evoked response of the H exposed groups. The results demonstrate that simultaneous exposure to H and light can lead to alterations in visual function that are more severe than those induced by each agent alone, and may exceed a simple summation.
将白化（斯普拉格-道利）和有色（挪威棕）雄性大鼠分别置于含2,5 -己二醇（H；1%）的饮用水中5周或8周。每个品系的一半大鼠饲养在光照环境下（笼内平均光照强度30 cd/cm²，每天12小时）；另一半饲养在持续黑暗环境中。对照组在相同条件下但不接触H进行平行研究。在接触H结束后2 - 5天和13周进行电生理记录。通过视网膜电图和视觉诱发电位测量发现，接触H和/或光照的白化大鼠组视觉系统出现改变。同时接触H和光照的白化大鼠组瞳孔直径增大。在有色大鼠中，仅在接触H的组的视觉诱发电位中记录到改变。结果表明，同时接触H和光照可导致视觉功能改变，这种改变比单独由每种因素引起的更严重，且可能超过简单的叠加效应。
