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[雌性大鼠麻醉作用中的乙醇药代动力学及内源性乙醇]

[Ethanol pharmacokinetics in narcotic action and endogenous ethanol in female rats].

作者信息

Andronova L M, Ushakova M M, Kudriavtsev R V, Barkov N K

出版信息

Biull Eksp Biol Med. 1982 Dec;94(12):60-2.

PMID:6891271
Abstract

Experiments were made on female rats to demonstrate a positive correlation between the time of ethanol anesthesia in estrus and diestrus and (1) subsequent preference of ethanol to water (r = 0.68) and (2) ethanol consumption dosage (r = 0.72). In the same rats (during estrus and diestrus), the endogenous level and blood concentrations of ethanol were measured 30 minutes after administering the anesthetic dose (4.5 g/kg) and during the animal's "egress" from anesthesia. The low level of endogenous ethanol and rapid decrease of the blood ethanol concentration upon administering the anesthetic dose during estrus were characteristic of those female rats which, under the conditions of free choice, preferred ethanol to water and consumed it in large doses.

摘要

对雌性大鼠进行了实验,以证明发情期和间情期乙醇麻醉时间与以下两者之间存在正相关关系:(1)随后对乙醇的偏好超过水(r = 0.68);(2)乙醇消耗剂量(r = 0.72)。在相同的大鼠中(发情期和间情期),在给予麻醉剂量(4.5 g/kg)后30分钟以及动物从麻醉中“苏醒”期间,测量了乙醇的内源性水平和血液浓度。发情期给予麻醉剂量后内源性乙醇水平低以及血液乙醇浓度迅速下降是那些在自由选择条件下偏好乙醇超过水并大量饮用乙醇的雌性大鼠的特征。

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[Ethanol pharmacokinetics in narcotic action and endogenous ethanol in female rats].[雌性大鼠麻醉作用中的乙醇药代动力学及内源性乙醇]
Biull Eksp Biol Med. 1982 Dec;94(12):60-2.
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