Pollock G A, DiSabatino C E, Heimsch R C, Hilbelink D R
Food Chem Toxicol. 1982 Dec;20(6):899-902. doi: 10.1016/s0015-6264(82)80225-3.
Alternariol monomethyl ether (AME), a metabolite of species of Alternaria, was studied for subchronic toxicity to rats and teratogenic effects in golden hamsters. In rats no toxic effects were observed at the highest dosage tested (3.75 mg given by oral gavage daily for 30 days). However, AME was maternally toxic and foetotoxic to Syrian golden hamsters when given ip at 200 mg/kg body weight on day 8 of gestation. No such effects were observed at dose levels of 50 or 100 mg/kg.
链格孢单甲醚（AME）是链格孢属物种的一种代谢产物，已对其进行大鼠亚慢性毒性和金黄仓鼠致畸作用的研究。在大鼠中，在测试的最高剂量（每天经口灌胃给予3.75毫克，持续30天）下未观察到毒性作用。然而，在妊娠第8天以200毫克/千克体重腹腔注射给予叙利亚金黄仓鼠时，AME对母体有毒性且对胎儿有毒性。在50或100毫克/千克的剂量水平下未观察到此类作用。
