在慢性喂养研究中高剂量次氮基三乙酸诱导的大鼠肾皮质损伤的可逆性

Reversibility of renal cortical lesions induced in rats by high doses of nitrilotriacetate in chronic feeding studies.

作者信息

Alden C L, Kanerva R L

出版信息

Food Chem Toxicol. 1982 Dec;20(6):935-7. doi: 10.1016/s0015-6264(82)80231-9.

Abstract

The effects in the renal cortex of the male rat of continuous administration of a high dose of nitrilotriacetate (NTA) for 24 months were compared with those of the administration of a similar dose for 18 months followed by a 6-month recovery period on the control diet. The results suggest that discontinuation of treatment interrupts the sequence of events leading to tumour formation. This study indicates that all stages in the proposed pathogenesis of renal tubular tumour formation by NTA, up to the occurrence of adenomatous hyperplasia and neoplasia, are reversible. Apparently, tumour development is dependent on the continuous administration of high doses of NTA in the presence of toxic injury to the majority of nephrons.

摘要

将高剂量次氮基三乙酸（NTA）连续给予雄性大鼠24个月对其肾皮质产生的影响，与给予相似剂量18个月后，再在对照饮食条件下恢复6个月所产生的影响进行了比较。结果表明，停止治疗会中断导致肿瘤形成的一系列事件。这项研究表明，在NTA诱发肾小管肿瘤形成的假定发病机制中，直至腺瘤样增生和肿瘤形成出现之前的所有阶段都是可逆的。显然，肿瘤的发展依赖于在大多数肾单位受到毒性损伤的情况下持续给予高剂量的NTA。