蛙皮素对人体固体食物胃排空的影响。

The effect of bombesin on gastric emptying of solids in man.

作者信息

Scarpignato C, Micali B, Vitulo F, Zimbaro G, Bertaccini G

出版信息

Peptides. 1981;2 Suppl 2:199-203. doi: 10.1016/0196-9781(81)90031-0.

Abstract

Intravenous infusion of bombesin (5 ng.kg(-1). min(-1) significantly delayed gastric emptying of solids in man. The gastrin response to meal increased following administration of the peptide; however no correlation was found between the difference in gastrin response (to meal alone and to meal plus bombesin) and the degree of delay in emptying. In addition the behavior of intragastric pH after eating was not modified by bombesin infusion. All of these data suggest a direct effect of the peptide on gastric emptying, which was probably connected with the strong contraction of the antrum and pylorus observed in this and in previous investigations.

摘要

静脉输注蛙皮素（5纳克·千克⁻¹·分钟⁻¹）可显著延迟人体固体食物的胃排空。给予该肽后，胃泌素对进餐的反应增强；然而，胃泌素反应差异（单独进餐与进餐加蛙皮素）与排空延迟程度之间未发现相关性。此外，进餐前后胃内pH值的变化不受蛙皮素输注的影响。所有这些数据表明该肽对胃排空有直接作用，这可能与本次及以往研究中观察到的胃窦和幽门的强烈收缩有关。