洛诺霉素B和C，聚醚抗生素的两个新组分。发酵、分离及特性研究。
Lonomycins B and C, two new components of polyether antibiotics. Fermentation, isolation and characterization.
作者信息
Mizutani T, Yamagishi M, Hara H, Omura S, Ozeki M, Mizoue K, Seto H, Otake N
出版信息
J Antibiot (Tokyo). 1980 Nov;33(11):1224-30. doi: 10.7164/antibiotics.33.1224.
Lonomycin B (II), C44H75O14Na, m.p. 181-182 degrees C, and lonomycin C (III), C43H73O14Na, m.p 186-187 degrees C, were isolated as their sodium salts from the fermentation broth of Streptomyces ribosidificus TM-481. Their physicochemical properties demonstrated that II and III are closely related congeners of lonomycin A (I). The identical mass spectra of methyl esters of I and II indicated that II is a stereoisomer of I. On the other hand, the mass spectrum of a methyl ester of III showed a peak at m/e 810 due to M+-H2O which is smaller by 14 mass units than the maximum peak at m/e 824 due to M+-H2O of the methyl esters of I and II. This result together with the elemental analysis strongly suggested that III is a demethyl derivative of I or II. II and III are slightly less active than I in their antimicrobial activities.
洛诺霉素B（II），化学式为C44H75O14Na，熔点181 - 182℃；洛诺霉素C（III），化学式为C43H73O14Na，熔点186 - 187℃，它们以钠盐形式从核糖苷链霉菌TM - 481的发酵液中分离得到。其物理化学性质表明，II和III是洛诺霉素A（I）紧密相关的同系物。I和II甲酯的质谱图相同，表明II是I的立体异构体。另一方面，III甲酯的质谱图在m/e 810处出现一个因M⁺ - H₂O产生的峰，比I和II甲酯因M⁺ - H₂O在m/e 824处的最大峰小14个质量单位。这一结果与元素分析有力地表明，III是I或II的去甲基衍生物。II和III的抗菌活性比I略低。
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