Thymann M
Hum Hered. 1981;31(4):214-21. doi: 10.1159/000153211.
Electrofocusing in agarose gel was used to investigate the distribution of subtypes of the group-specific component in a Danish population sample (n = 1,674). The frequencies observed were Gc1S = 0.5717, Gc1F = 0.1589, Gc2 = 0.2688. The rare allele Gc 1C3 was encountered with a frequency of 0.0006. Studies of 81 families with 198 children and 466 mother-child pairs confirmed the assumed three-allelic mode of inheritance. The application of Gc subtyping to paternity testing was investigated by examination of 208 cases involving 287 men. The reliability of exclusions of paternity performed by means of the extended Gc system is discussed with special attention to the occurrence of silent alleles.
采用琼脂糖凝胶电聚焦法研究丹麦人群样本（n = 1674）中群体特异性成分亚型的分布。观察到的频率为Gc1S = 0.5717，Gc1F = 0.1589，Gc2 = 0.2688。罕见等位基因Gc 1C3的出现频率为0.0006。对81个家庭（198名儿童和466对母婴）的研究证实了假定的三等位基因遗传模式。通过检查208例涉及287名男性的案例，研究了Gc亚型在亲子鉴定中的应用。讨论了通过扩展Gc系统进行父权排除的可靠性，并特别关注沉默等位基因的出现情况。
