原发性干燥综合征患者维生素D3代谢异常。
Abnormal vitamin D3 metabolism in patients with primary Sjögren's syndrome.
作者信息
Müller K, Oxholm P, Sørensen O H, Thymann M, Høier-Madsen M, Bendtzen K
机构信息
Medical Department TTA, Rigshospitalet, State University Hospital, Copenhagen, Denmark.
出版信息
Ann Rheum Dis. 1990 Sep;49(9):682-4. doi: 10.1136/ard.49.9.682.
Abstract
Recent studies have suggested that vitamin D3 may have an immunoregulatory role in vitro. The vitamin D3 metabolism in 35 patients with primary Sjögren's syndrome was investigated by measuring blood concentrations of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) and 25-hydroxyvitamin D3 (25-OHD3), as well as phenotypes and blood concentrations of Gc globulin, the main vitamin D3 binding protein in the blood. 25-OHD3 concentrations were diminished, but those of 1 alpha,25-(OH)2D3 were normal. There was no significant difference between the distribution of Gc phenotypes in the patients with primary Sjögren's syndrome and normal controls. Likewise, blood concentrations of Gc globulin corresponded to normal values. Among patients with increased concentrations of IgM rheumatoid factor there was a significant negative correlation between the serum titres of IgM rheumatoid factor and 25-OHD3 concentrations.
摘要
近期研究表明，维生素D3在体外可能具有免疫调节作用。通过测量血液中1α,25 - 二羟基维生素D3（1α,25-(OH)2D3）和25 - 羟基维生素D3（25 - OHD3）的浓度，以及血液中主要维生素D3结合蛋白Gc球蛋白的表型和血液浓度，对35例原发性干燥综合征患者的维生素D3代谢情况进行了研究。25 - OHD3浓度降低，但1α,25-(OH)2D3浓度正常。原发性干燥综合征患者与正常对照组之间Gc表型的分布无显著差异。同样，Gc球蛋白的血液浓度与正常值相符。在IgM类风湿因子浓度升高的患者中，IgM类风湿因子的血清滴度与25 - OHD3浓度之间存在显著负相关。
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