Bernström K, Hammarström S
J Biol Chem. 1981 Sep 25;256(18):9579-82.
An enzyme from porcine kidney converted leukotriene D4 into a less polar metabolite. The structure of this compound was 5-hydroxy-6-S-cysteinyl-7,9-trans-11,14-cis-eicosatetraenoic acid (leukotriene E4). Analogous products, viz. 5-hydroxy-6-S-cysteinyl-7,9,11-eicosatrienoic acid (leukotriene E3), 5-hydroxy-6-S-cysteinyl-7,9,11-trans-14-cis-eicosatetraenoic acid (11-trans-leukotriene E4), and 5-hydroxy-6-S-cysteinyl-7,9,11,14,17-eicosapentaenoic acid (leukotriene E5) were formed from leukotrienes D3, 11-trans-D4, and D5, respectively. Leukotriene E4 induced slow reacting substance-like contractions of guinea pig ileum but was less potent (8-12 times) than leukotriene C4. The biological potency of 11-trans-leukotriene E4 was similar to that of leukotriene E4.
来自猪肾的一种酶将白三烯D4转化为一种极性较小的代谢产物。该化合物的结构为5-羟基-6-S-半胱氨酰基-7,9-反式-11,14-顺式-二十碳四烯酸（白三烯E4）。类似的产物，即5-羟基-6-S-半胱氨酰基-7,9,11-二十碳三烯酸（白三烯E3）、5-羟基-6-S-半胱氨酰基-7,9,11-反式-14-顺式-二十碳四烯酸（11-反式-白三烯E4）和5-羟基-6-S-半胱氨酰基-7,9,11,14,17-二十碳五烯酸（白三烯E5）分别由白三烯D3、11-反式-D4和D5形成。白三烯E4诱导豚鼠回肠出现类似慢反应物质的收缩，但效力比白三烯C4弱（8 - 12倍）。11-反式-白三烯E4的生物学效力与白三烯E4相似。
