Safford K L, Spebar M J, Rosenthal D
Am J Surg. 1981 Dec;142(6):767-9. doi: 10.1016/0002-9610(81)90331-7.
Brooke Army Medical Center Tumor Registry records from 1947 through 1980 were reviewed. One hundred forty of 819 patients with colorectal cancer were aged 40 or less. The 5 year survival rate was 35 percent and the 10 year survival rate 32 percent. The predominant presenting symptoms were bleeding, pain and change of bowel habits. The median duration of symptoms was 3 months. There were no Dukes'A patients. The 5 and 10 year survival rates in 19 Dukes' B patients were 67 percent. Thirty-three Dukes' C patients had 5 and 10 year survival rates of 37 and 30 percent, respectively. In 42 Dukes' D patients, however, there were no 5 year survivors, and the mean length of survival was only 10 months. Our findings support previous surveys which have concluded that stage at the time of diagnosis, rather than symptoms, duration or patient age, is the most accurate prognostic factor.
回顾了布鲁克陆军医疗中心1947年至1980年的肿瘤登记记录。819例结直肠癌患者中有140例年龄在40岁及以下。5年生存率为35%，10年生存率为32%。主要的首发症状是出血、疼痛和排便习惯改变。症状的中位持续时间为3个月。没有Dukes'A期患者。19例Dukes'B期患者的5年和10年生存率为67%。33例Dukes'C期患者的5年和10年生存率分别为37%和30%。然而，在42例Dukes'D期患者中，没有5年生存者，平均生存时间仅为10个月。我们的研究结果支持先前的调查，这些调查得出结论，诊断时的分期而非症状、持续时间或患者年龄是最准确的预后因素。
