Buchino J J, Byrd R P, Kmetz D R
Arch Pathol Lab Med. 1982 Jan;106(1):13-6.
Sinus histiocytosis with massive lymphadenopathy (SHML) is generally regarded as a benign, self-limited, pseudolymphomatous process requiring little or no therapy. We studied a 13-year-old black boy with a ten-year clinical course of SHML that had varying, intermittent sites of extranodal involvement, including bone, submandibular gland, trachea, eye, and spinal cord. At the time of death, which was attributed to SHML, additional extranodal sites of involvement included thymus, kidney, heart, liver, and base of brain. Microscopic examination of the SHML lesions at the time of autopsy revealed varying stages of development, from proliferation to involution. This case illustrates that SHML may involve multiple organ systems, can kill, and that histologic evaluation of disease activity at one site cannot be used as an indicator of activity at another.
伴巨大淋巴结病的窦性组织细胞增生症（SHML）通常被认为是一种良性、自限性的假淋巴瘤过程，几乎无需治疗。我们研究了一名13岁的黑人男孩，其SHML临床病程长达10年，结外受累部位多变且呈间歇性，包括骨骼、下颌下腺、气管、眼睛和脊髓。在因SHML死亡时，其他结外受累部位包括胸腺、肾脏、心脏、肝脏和脑底部。尸检时对SHML病变的显微镜检查显示出从增殖到消退的不同发育阶段。该病例表明，SHML可能累及多个器官系统，可导致死亡，且一个部位疾病活动的组织学评估不能用作另一个部位活动的指标。
