Foucar E, Rosai J, Dorfman R F
Arch Otolaryngol. 1978 Dec;104(12):687-93.
Sinus histiocytosis with massive lymphadenopathy (SHML) is a newly recognized, distinct, pseudolymphomatous benign entity with very characteristic microscopic features. Most patients are children or young adults with massive painless cervical adenopathy, although other node groups and extranodal sites often are involved. Sixteen patients with SHML involving the upper respiratory tract and/ or salivary gland are presented. Nine of the patients had ear, nose, and throat (ENT) manifestations at the time of presentation. In most cases the ENT involvement resulted in prominent clinical symptoms. Treatment included surgery, antibiotics, irradiation, chemotherapy, and steroids, frequently in combination, but no consistent pattern of response emerged from the study. These 16 patients were very similar clinically to patients with SHML who did not have ENT disease, indicating that extranodal involvement is not associated with more aggressive disease.
伴巨大淋巴结病的窦性组织细胞增生症（SHML）是一种新认识的、独特的、具有非常特征性微观特征的假性淋巴瘤良性病变。大多数患者为儿童或年轻成人，有巨大无痛性颈部淋巴结病，尽管其他淋巴结组和结外部位也常受累。本文报告了16例累及上呼吸道和/或唾液腺的SHML患者。9例患者在就诊时有耳鼻喉（ENT）表现。在大多数情况下，ENT受累导致明显的临床症状。治疗包括手术、抗生素、放疗、化疗和类固醇，通常联合使用，但该研究未出现一致的反应模式。这16例患者在临床上与无ENT疾病的SHML患者非常相似，表明结外受累与更具侵袭性的疾病无关。
