Brock-Utne J G, Kallichurum S, Mankowitz E, Maharaj R J, Downing J W
S Afr Med J. 1982 Mar 20;61(12):440-1.
Ketamine, an analgesic-cataleptic drug, provides pain relief without respiratory depression. Ketamine with the preservative benzethonium chloride 0.1 mg/ml was injected intrathecally into 4 baboons under Ketamine anaesthesia. A control group of 2 baboons received intrathecal saline. No assessment as to relief from experimental pain was possible, but all the baboons recovered normally from anaesthesia and were found moving about in their enclosures without gross evidence of neurological impairment. No adverse reactions were noted. One month after the intrathecal injection the baboons were sacrificed, and an autopsy was performed within 30 minutes. No macroscopic abnormally of the cord was noticed. Microscopic examination revealed oedema of a few nerve roots in all animals irrespective of whether ketamine or saline had been injected intrathecally. No other changes attributable to ketamine were seen, and its is therefore concluded that, in the doses given, intrathecally injected ketamine would seem to be safe.
氯胺酮是一种具有镇痛和催化作用的药物，能缓解疼痛且不会导致呼吸抑制。在氯胺酮麻醉下，将含有0.1毫克/毫升苯扎氯铵防腐剂的氯胺酮鞘内注射到4只狒狒体内。一个由2只狒狒组成的对照组接受鞘内注射生理盐水。虽然无法评估实验性疼痛是否得到缓解，但所有狒狒均从麻醉中正常恢复，且发现它们在围栏内活动，没有明显的神经功能损害迹象。未观察到不良反应。鞘内注射一个月后，处死狒狒，并在30分钟内进行尸检。未发现脊髓有宏观异常。显微镜检查显示，无论鞘内注射的是氯胺酮还是生理盐水，所有动物的一些神经根均有水肿。未观察到其他可归因于氯胺酮的变化，因此得出结论，在所给剂量下，鞘内注射氯胺酮似乎是安全的。
