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编码肌肉收缩蛋白、肌球蛋白重链、肌球蛋白轻链2和骨骼肌肌动蛋白的基因位于三条不同的小鼠染色体上。

The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes.

作者信息

Czosnek H, Nudel U, Shani M, Barker P E, Pravtcheva D D, Ruddle F H, Yaffe D

出版信息

EMBO J. 1982;1(11):1299-305. doi: 10.1002/j.1460-2075.1982.tb01314.x.

DOI:10.1002/j.1460-2075.1982.tb01314.x
PMID:6897916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC553208/
Abstract

The chromosomal distribution of murine genes expressed during differentiation of skeletal muscle cells was determined by Southern blot analysis of DNA from mouse-Chinese hamster hybrid cell lines containing incomplete subsets of mouse chromosomes. All detectable myosin heavy chain genes are located on chromosome 11. The gene for the myosin light chain 2 is located on chromosome 7. The skeletal muscle alpha-actin gene and several other actin genes, or pseudogenes, are located on chromosome 3. Additional actin DNA sequences are distributed on other mouse chromosomes.

摘要

通过对含有小鼠染色体不完全子集的小鼠 - 中国仓鼠杂交细胞系的DNA进行Southern印迹分析，确定了骨骼肌细胞分化过程中表达的小鼠基因的染色体分布。所有可检测到的肌球蛋白重链基因都位于11号染色体上。肌球蛋白轻链2基因位于7号染色体上。骨骼肌α - 肌动蛋白基因和其他几个肌动蛋白基因或假基因位于3号染色体上。其他肌动蛋白DNA序列分布在小鼠的其他染色体上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/9058800d3e17/emboj00303-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/3fe3b6f87432/emboj00303-0013-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/cf76e21b2b39/emboj00303-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/2f2b01d3a9e2/emboj00303-0015-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/9058800d3e17/emboj00303-0016-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/3fe3b6f87432/emboj00303-0013-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/cf76e21b2b39/emboj00303-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/2f2b01d3a9e2/emboj00303-0015-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a24/553208/9058800d3e17/emboj00303-0016-a.jpg

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The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes.编码肌肉收缩蛋白、肌球蛋白重链、肌球蛋白轻链2和骨骼肌肌动蛋白的基因位于三条不同的小鼠染色体上。
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The genes coding for the cardiac muscle actin, the skeletal muscle actin and the cytoplasmic beta-actin are located on three different mouse chromosomes.
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