独特型决定簇的演变：抗缬氨酸
Evolution of an idiotypic determinant: anti-Val.
作者信息
Karol R A, Reichlin M, Noble R W
出版信息
J Exp Med. 1977 Aug 1;146(2):435-44. doi: 10.1084/jem.146.2.435.
An antibody population which reacts only with human sickle cell hemoglobin (HbS) and not with normal human hemoglobin, has been isolated from goat, sheep, and guinea pig antisera. These antibody populations termed anti-Val (Val), isolated from an individual goat (no. 6) and sheep (no. 26) have been used to elicit anti-idiotypic responses in rabbits. These anti-idiotypic sera were used to study the idiotypic cross-reactions between the goat and sheep anti-Val. Strong cross-reactions were present using either Ra anti-goat anti-Val or Ra anti-sheep anti-Val. Guinea pig anti-Val did not cross-react with these anti-idiotypic sera. Binding of HbS to the anti-Val of the goat and sheep could be blocked by the anti-idiotypic sera, but the binding of HbS to the guinea pig anti-Val could not. These data demonstrate idiotypic cross-reactivity between two closely related species.
已从山羊、绵羊和豚鼠抗血清中分离出仅与人镰状细胞血红蛋白（HbS）反应而不与正常人血红蛋白反应的抗体群体。从一只山羊（6号）和一只绵羊（26号）分离出的这些被称为抗缬氨酸（Val）的抗体群体已用于在兔子中引发抗独特型反应。这些抗独特型血清用于研究山羊和绵羊抗Val之间的独特型交叉反应。使用兔抗山羊抗Val或兔抗绵羊抗Val时均存在强烈的交叉反应。豚鼠抗Val与这些抗独特型血清不发生交叉反应。抗独特型血清可阻断HbS与山羊和绵羊抗Val的结合，但不能阻断HbS与豚鼠抗Val的结合。这些数据证明了两个密切相关物种之间的独特型交叉反应性。
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