Carson D, Weigert M
Proc Natl Acad Sci U S A. 1973 Jan;70(1):235-9. doi: 10.1073/pnas.70.1.235.
The idiotype of the mouse myeloma protein with anti-alpha-1,3 dextran activity, J558, has been characterized by a solid-phase radioimmunoassay. The idiotype of the J558 protein depends on a specific light and heavy chain interaction and is altered in the presence of the hapten, nigerose. Cross-reacting idiotypes were found on another mouse myeloma protein with alpha1,3 dextran specificity, normal anti-dextran antibody, and certain reconstructed myeloma proteins composed of the J558 heavy chain and heterologous light chains.
具有抗α-1,3-葡聚糖活性的小鼠骨髓瘤蛋白J558的独特型已通过固相放射免疫测定法进行了表征。J558蛋白的独特型取决于特定的轻链和重链相互作用,并且在半抗原黑曲霉糖存在的情况下会发生改变。在另一种具有α1,3-葡聚糖特异性的小鼠骨髓瘤蛋白、正常抗葡聚糖抗体以及某些由J558重链和异源轻链组成的重组骨髓瘤蛋白上发现了交叉反应独特型。