对具有抗右旋糖酐活性的小鼠骨髓瘤蛋白和正常抗右旋糖酐抗体的交叉反应独特型进行免疫化学分析。
Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody.
作者信息
Carson D, Weigert M
出版信息
Proc Natl Acad Sci U S A. 1973 Jan;70(1):235-9. doi: 10.1073/pnas.70.1.235.
Abstract
The idiotype of the mouse myeloma protein with anti-alpha-1,3 dextran activity, J558, has been characterized by a solid-phase radioimmunoassay. The idiotype of the J558 protein depends on a specific light and heavy chain interaction and is altered in the presence of the hapten, nigerose. Cross-reacting idiotypes were found on another mouse myeloma protein with alpha1,3 dextran specificity, normal anti-dextran antibody, and certain reconstructed myeloma proteins composed of the J558 heavy chain and heterologous light chains.
摘要
具有抗α-1,3-葡聚糖活性的小鼠骨髓瘤蛋白J558的独特型已通过固相放射免疫测定法进行了表征。J558蛋白的独特型取决于特定的轻链和重链相互作用，并且在半抗原黑曲霉糖存在的情况下会发生改变。在另一种具有α1,3-葡聚糖特异性的小鼠骨髓瘤蛋白、正常抗葡聚糖抗体以及某些由J558重链和异源轻链组成的重组骨髓瘤蛋白上发现了交叉反应独特型。
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