针对流感病毒的人类细胞毒性T淋巴细胞的HLA限制。与HLA A2相关的病毒识别能力较差。
HLA restriction of human cytotoxic T lymphocytes specific for influenza virus. Poor recognition of virus associated with HLA A2.
作者信息
McMichael A
出版信息
J Exp Med. 1978 Dec 1;148(6):1458-67. doi: 10.1084/jem.148.6.1458.
Abstract
Cytotoxic T lymphocytes (CTL), specific for influenza A/X31 virus, were generated from human peripheral blood lymphocytes. These CTL lysed target cells that were infected with the same virus and that shared HLA A or B locus antigens. Minimal lysis was observed when HLA-D antigens were shared. Not all HLA A and B antigens were equally effective. Efficient lysis of target cells was seen when HLA A1, A3, B7, B8, B27 and BW21 were shared with the CTL, but when HLA A2 was the only shared antigen lysis was usually minimal. This deficiency in CTL function associated with HLA A2 was not absolute. It is suggested that the function of this antigen might be influenced by other surface molecules on the cell and in particular the other HLA products.
摘要
针对甲型流感病毒/X31的细胞毒性T淋巴细胞（CTL）由人外周血淋巴细胞产生。这些CTL可裂解感染相同病毒且共享HLA A或B位点抗原的靶细胞。当共享HLA-D抗原时，观察到的细胞裂解极少。并非所有的HLA A和B抗原都具有同等效力。当CTL共享HLA A1、A3、B7、B8、B27和BW21时，可观察到靶细胞的有效裂解，但当HLA A2是唯一共享抗原时，细胞裂解通常极少。与HLA A2相关的CTL功能缺陷并非绝对的。提示该抗原的功能可能受细胞上其他表面分子尤其是其他HLA产物的影响。
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