Department of Medicine, Lifespan/Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA.
Virulence. 2012 Aug 15;3(5):421-33. doi: 10.4161/viru.21282.
Enterococci have the potential for resistance to virtually all clinically useful antibiotics. Their emergence as important nosocomial pathogens has coincided with increased expression of antimicrobial resistance by members of the genus. The mechanisms underlying antibiotic resistance in enterococci may be intrinsic to the species or acquired through mutation of intrinsic genes or horizontal exchange of genetic material encoding resistance determinants. This paper reviews the antibiotic resistance mechanisms in Enterococcus faecium and Enterococcus faecalis and discusses treatment options.
肠球菌具有几乎对所有临床有用的抗生素的耐药潜力。随着该属成员对抗微生物药物耐药性表达的增加，它们作为重要的医院获得性病原体出现。肠球菌中抗生素耐药性的机制可能是物种固有的，也可能是通过内在基因的突变或编码耐药决定因素的遗传物质的水平交换获得的。本文综述了屎肠球菌和粪肠球菌的抗生素耐药机制，并讨论了治疗选择。
