Bayer A S, Chow A W, Morrison J O, Guze L B
Antimicrob Agents Chemother. 1980 Mar;17(3):359-63. doi: 10.1128/AAC.17.3.359.
The bactericidal activities of penicillin G and ampicillin alone were compared with those of their combinations with streptomycin or gentamicin against 17 strains of lactobacilli classified as tolerant to various beta-lactam antibiotics. The penicillin G combinations with streptomycin and gentamicin were synergistic against 17 and 16 of these strains, respectively, whereas the corresponding ampicillin-aminoglycoside combinations were synergistic against 12 and 15 strains, respectively. Importantly, synergy was manifested at concentrations of these antibiotics that are attained in serum after their administration in conventional dose regimens. In no instances were combinations antagonistic. These in vitro observations provide a partial explanation for the favorable results obtained in preliminary clinical evaluations of the benefits of combination regimens in the treatment of lactobacillus infections refractory to single-drug therapy.
将青霉素G和氨苄西林单独的杀菌活性，与其分别与链霉素或庆大霉素联合使用时对17株被分类为对各种β-内酰胺抗生素耐受的乳酸杆菌的杀菌活性进行了比较。青霉素G与链霉素和庆大霉素的联合用药分别对其中17株和16株菌株具有协同作用，而相应的氨苄西林-氨基糖苷类联合用药分别对12株和15株菌株具有协同作用。重要的是，在按照常规剂量方案给药后，血清中可达到的这些抗生素浓度下即表现出协同作用。在任何情况下联合用药均无拮抗作用。这些体外观察结果为联合用药方案治疗单药治疗难治的乳酸杆菌感染的初步临床评估中获得的良好结果提供了部分解释。
