Krueger G G, Hill H R, Jederberg W W
J Invest Dermatol. 1978 Sep;71(3):189-94. doi: 10.1111/1523-1747.ep12547129.
Intradermal skin testing of normal and psoriatic subjects with common antigens, SKSD, Derm-O and PPD, reveals psoriatic subjects to have a decrease in both the amount (not incidence) of erythema (p less than 0.005) and in-duration (p less 0.005) to SKSD. Among all subjects having more than 10 mm erythema to Derm-O and SKSD, 49% of psoriatic and 77% of normal subjects have more than 10 mm induration (p less than 0.001). After sensitization, the response to 30 microgram challenge dose of dinitrochlorobenzene is positive in 50% of psoriatic and 88% of normal subjects (p less than 0.02). Uptake of (3)H thymidine by mitogen stimulated lymphocytes from psoriatic subjects is suppressed at each point of the linear component of a dose response curve. The mitogen dose to produce peak responses in psoriatics was 125% greater than that for normal subjects. In one-way mixed lymphocyte responses to pooled allogeneic stimulator lymphocytes, peripheral blood mononuclear cells from psoriatic subjects show suppression, the mean stimulation index was 55% of that of normal (p less than 0.01). Finally, in vitro polymorphonuclear leukocyte functions (chemotaxis, phagocytosis, and NBT reduction) appear to be within normal limits. When the foregoing parameters were compared with disease activity, there was no correlation.
对正常人和银屑病患者用常见抗原SKSD、Derm - O和PPD进行皮内皮肤试验，结果显示银屑病患者对SKSD的红斑量（而非发生率）和持续时间均减少（p小于0.005）。在对Derm - O和SKSD产生超过10毫米红斑的所有受试者中，49%的银屑病患者和77%的正常受试者硬结超过10毫米（p小于0.001）。致敏后，30微克二硝基氯苯激发剂量的反应在50%的银屑病患者和88%的正常受试者中呈阳性（p小于0.02）。在剂量反应曲线的线性部分的每个点，银屑病患者经丝裂原刺激的淋巴细胞对（3）H胸腺嘧啶核苷的摄取均受到抑制。在银屑病患者中产生峰值反应的丝裂原剂量比正常受试者大125%。在对混合的同种异体刺激淋巴细胞的单向混合淋巴细胞反应中，银屑病患者的外周血单个核细胞表现出抑制，平均刺激指数为正常受试者的55%（p小于0.01）。最后，体外多形核白细胞功能（趋化性、吞噬作用和NBT还原）似乎在正常范围内。当将上述参数与疾病活动度进行比较时，未发现相关性。
