Krueger G G, Jederberg W W, Ogden B E, Reese D L
J Invest Dermatol. 1978 Sep;71(3):195-201. doi: 10.1111/1523-1747.ep12547138.
We have previously confirmed that subjects with psoriasis have an alteration of cell-mediated immune responses. We now report a possible in vitro corollary; the amount of lymphokine (lymphocyte-derived chemotactic factor) released by both antigen-stimulated and control lymphocytes is decreased in psoriatic subjects; 61% of similar values for normal subjects. Monocyte migration to complement-derived chemotactic factors is reported to directly correlate to skin tests; however, in psoriasis the relation is inverse, i.e., a 200% increase in complement factors and 136% increase to lymphocyte-derived chemotactic factor in monocyte migration is noted in psoriatic subjects when compared with normal subjects. This increased migration does not correlate with amount of disease and is still present in "disease-free" subjects. Culturing monocytes from psoriatic subjects in media alone demonstrates they reduce more (205%) nitroblue tetrazolium than do monocytes of normal subjects. These data demonstrate that monocytes from subjects with psoriasis are altered and suggest an apparent inherent metabolic disorder.
我们之前已经证实，银屑病患者存在细胞介导的免疫反应改变。我们现在报告一个可能的体外推论；银屑病患者中，抗原刺激淋巴细胞和对照淋巴细胞释放的淋巴因子（淋巴细胞衍生趋化因子）量均减少；仅为正常受试者类似值的61%。据报道，单核细胞向补体衍生趋化因子的迁移与皮肤试验直接相关；然而，在银屑病中这种关系是相反的，即与正常受试者相比，银屑病患者单核细胞迁移中补体因子增加200%，淋巴细胞衍生趋化因子增加136%。这种增加的迁移与疾病程度无关，在“无病”受试者中仍然存在。仅在培养基中培养银屑病患者的单核细胞表明，它们比正常受试者的单核细胞还原更多（205%）的硝基蓝四氮唑。这些数据表明，银屑病患者的单核细胞发生了改变，并提示存在明显的内在代谢紊乱。
