Aminoff M J, Ehsanullah R S, Turner P
J Neurol Neurosurg Psychiatry. 1978 Jul;41(7):589-92. doi: 10.1136/jnnp.41.7.589.
The uptake of tritiated dopamine and 5-hydroxytryptamine by platelets from 11 patients with Parkinsonism who were not receiving any medication, and from 11 control subjects matched for sex and for age within a decade was compared. No significant differences were found in the uptake of either amine. Our findings, therefore, provide no support for the belief that there is a generalised defect of dopamine systems in Parkinson's disease.
对11名未接受任何药物治疗的帕金森病患者以及11名年龄和性别匹配、年龄相差不超过10岁的对照受试者的血小板摄取氚标记多巴胺和5-羟色胺的情况进行了比较。未发现两种胺类摄取存在显著差异。因此,我们的研究结果不支持帕金森病存在多巴胺系统普遍缺陷这一观点。