帕金森病患者血小板对多巴胺和5-羟色胺的摄取
Uptake of dopamine and 5-hydroxytryptamine by platelets of patients with Parkinsonism.
作者信息
Aminoff M J, Ehsanullah R S, Turner P
出版信息
J Neurol Neurosurg Psychiatry. 1978 Jul;41(7):589-92. doi: 10.1136/jnnp.41.7.589.
Abstract
The uptake of tritiated dopamine and 5-hydroxytryptamine by platelets from 11 patients with Parkinsonism who were not receiving any medication, and from 11 control subjects matched for sex and for age within a decade was compared. No significant differences were found in the uptake of either amine. Our findings, therefore, provide no support for the belief that there is a generalised defect of dopamine systems in Parkinson's disease.
摘要
对11名未接受任何药物治疗的帕金森病患者以及11名年龄和性别匹配、年龄相差不超过10岁的对照受试者的血小板摄取氚标记多巴胺和5-羟色胺的情况进行了比较。未发现两种胺类摄取存在显著差异。因此，我们的研究结果不支持帕金森病存在多巴胺系统普遍缺陷这一观点。
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Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with L-DOPA.正常受试者以及接受左旋多巴治疗的帕金森病患者血小板对多巴胺的摄取。
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Serotonin content of platelet enriched plasma in Parkinson patients prior and during treatment with L-3,4-dihydroxyphenylalanine (L-DOPA).帕金森病患者在使用L-3,4-二羟基苯丙氨酸（L-DOPA）治疗前及治疗期间富含血小板血浆中的血清素含量。
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