Michell A R
Q J Exp Physiol. 1981 Oct;66(4):515-24. doi: 10.1113/expphysiol.1981.sp002592.
Food and water intake were restricted by 29% for 48 h in ovariectomized ewes, to see whether such changes could cause a pattern of water and electrolyte excretion similar to that observed during the oestrous cycle. The closest resemblance appeared in the effect on water balance and there was also a rise in sodium excretion, as at oestrus. Restriction of intake failed to duplicate the marked sodium retention or, more particularly, the persistent potassium retention which follow natural oestrus. Restriction of food alone produced changes less similar to those seen at oestrus, mainly because this treatment caused a large increase in urine output. The similarity between the effects of restriction and 'fasting natriuresis' is discussed, with particular reference to the mildness of the stimulus in these experiments. Indications that the gut may be as important as the kidney in the regulation of salt and water balance are discussed in relation to other herbivores and to man.
对去卵巢母羊的食物和水摄入量进行了48小时29%的限制，以观察这种变化是否会导致一种与发情周期中观察到的水和电解质排泄模式相似的情况。最相似之处出现在对水平衡的影响上，而且钠排泄也有所增加，与发情期时一样。摄入量的限制未能重现自然发情后明显的钠潴留，尤其是持续的钾潴留。仅限制食物产生的变化与发情期观察到的变化不太相似，主要是因为这种处理导致尿量大幅增加。讨论了限制作用与“饥饿性利钠”作用之间的相似性，特别提及了这些实验中刺激的温和程度。结合其他食草动物和人类，讨论了肠道在盐和水平衡调节中可能与肾脏同样重要的迹象。
