McKenna T M, Haines H
Am J Physiol. 1981 May;240(5):R319-26. doi: 10.1152/ajpregu.1981.240.5.R319.
Changes in sodium and potassium balance and urinary aldosterone excretion (free plus "acid labile") were surveyed in house mice acclimating initially to 1/2 the ad libitum water ration and later to 1/4 of ad libitum. Each water restriction caused negative sodium and potassium balance, followed by conservation of both ions. At the first water restriction, negative balance was produced by natriuresis and kaliuresis, at successive water restriction, a negative balance was due to a decrease in food consumption. Aldosterone excretion doubled at the 1/2 ad libitum restriction, and then generally remained at control levels thereafter. Fractional intestinal absorption of both ions showed a persistent increase after the 3rd day of water restriction. The Na:K ratio in urine and feces declined as mice responded to each water restriction and returned to control levels in acclimated animals.
对最初适应自由饮水量一半、后来适应自由饮水量四分之一的家鼠的钠和钾平衡变化以及尿醛固酮排泄（游离加“酸不稳定”）进行了调查。每次限水都会导致钠和钾的负平衡，随后两种离子都会得到保留。在第一次限水时，负平衡是由利钠和利尿引起的，在连续限水时，负平衡是由于食物摄入量减少。醛固酮排泄在自由饮水量限制为一半时增加了一倍，此后通常保持在对照水平。限水第三天后，两种离子的肠道吸收分数持续增加。随着小鼠对每次限水做出反应，尿液和粪便中的钠钾比下降，并在适应的动物中恢复到对照水平。
