Stockley R A, Ohlsson K
Thorax. 1982 Feb;37(2):114-7. doi: 10.1136/thx.37.2.114.
Immunoreactive leucocyte elastase was measured in the serum of patients with chronic obstructive bronchitis. No evidence was found to demonstrate the release of this enzyme in the pulmonary circulation. However the average serum concentrations (573 . 0 micrograms/l; SD +/- 261 . 0) were higher (2p less than 0 . 001) in this group of patients than in age matched control subjects (355 . 2 micrograms/l; SD +/- 274 . 8). Further studies confirmed this finding but patients with other active lung diseases had similarly increased leucocyte elastase concentration in the serum. This suggests that a raised serum leucocyte elastase concentration is a feature of active lung diseases and not a feature of obstructive bronchitis alone.
对慢性阻塞性支气管炎患者的血清进行了免疫反应性白细胞弹性蛋白酶检测。未发现有证据表明该酶在肺循环中释放。然而，该组患者的平均血清浓度（573.0微克/升；标准差±261.0）高于年龄匹配的对照组（355.2微克/升；标准差±274.8）（P<0.001）。进一步研究证实了这一发现，但其他活动性肺部疾病患者的血清白细胞弹性蛋白酶浓度也同样升高。这表明血清白细胞弹性蛋白酶浓度升高是活动性肺部疾病的一个特征，而非仅为阻塞性支气管炎所特有。
