Casal J
Antimicrob Agents Chemother. 1982 Aug;22(2):222-5. doi: 10.1128/AAC.22.2.222.
This study examined the resistance to penicillin, tetracycline, erythromycin, and chloramphenicol of 318 pneumococcal strains isolated in Spanish hospitals from blood or cerebrospinal fluid of patients during 1979 to 1981. The serotypes of these strains were determined to discover whether a correlation between serotype and patterns of antibiotic resistance could be found. Seven and nine patterns of resistance were found in strains isolated from blood and cerebrospinal fluid, respectively; tetracycline was the most frequent pattern, followed by tetracycline associated with chloramphenicol. A random distribution of serotypes which was similar to the general distribution of serotypes was found for resistance to tetracycline and chloramphenicol, but penicillin-resistant strains were confined to seven serotypes. Thirty-six strains of penicillin-resistant pneumococci isolated from sources other than blood or cerebrospinal fluid were also serotyped. They represented the same serotypes, suggesting that serotype distribution among penicillin-resistant strains could be a manifestation of local epidemiological factors.
本研究检测了1979年至1981年期间从西班牙医院患者的血液或脑脊液中分离出的318株肺炎球菌对青霉素、四环素、红霉素和氯霉素的耐药性。确定这些菌株的血清型，以发现血清型与抗生素耐药模式之间是否存在相关性。从血液和脑脊液中分离出的菌株分别发现了7种和9种耐药模式；四环素是最常见的模式，其次是四环素与氯霉素相关的模式。对于四环素和氯霉素耐药性，发现血清型呈随机分布，与血清型的总体分布相似，但耐青霉素菌株局限于7种血清型。还对从血液或脑脊液以外的来源分离出的36株耐青霉素肺炎球菌进行了血清分型。它们代表相同的血清型，这表明耐青霉素菌株中的血清型分布可能是当地流行病学因素的一种表现。
