用2,4-二氯苯氧乙酸丁酯处理的鸡蛋所孵化出的雏鸡大脑的孵化情况及脂质组成

Hatching and lipid composition of chicks brain from eggs treated with 2,4-dichlorophenoxyacetic butyl ester.

作者信息

Duffard R, de Moro G M, de Duffard A M

出版信息

Toxicology. 1982;24(3-4):305-11. doi: 10.1016/0300-483x(82)90012-9.

Abstract

Fertilized hen's eggs were painted, before starting incubation, with solutions of commercial 2,4-dichlorophenoxyacetic butyl ester, (0.8 mg, 3.1 mg, 6.3 mg, 9.4 mg and 12.1 mg of pure drug) in ether. Hatchability studies suggest that the fetotoxic effects observed are related to the drug concentration. There are no statistically significant differences between control and treated groups in body weight, cerebral wet, and dry weights and water content. Protein and total lipid levels are dose dependently decreased. Phospholipids are significantly diminished in the 6.3 mg of 2,4-dichlorophenoxyacetic butyl ester group. Gangliosides are increased while cholesterol and glycolipids are diminished; their decrease is inverse to drug concentration. A decrease in glycolipids suggests an alteration of the normal process of myelination.

摘要

在开始孵化前，将受精的鸡蛋用商业用2,4-二氯苯氧基乙酸丁酯（分别含0.8毫克、3.1毫克、6.3毫克、9.4毫克和12.1毫克纯药物）的乙醚溶液进行涂抹。孵化率研究表明，观察到的胚胎毒性作用与药物浓度有关。对照组和处理组在体重、脑湿重、干重和含水量方面没有统计学上的显著差异。蛋白质和总脂质水平呈剂量依赖性下降。在6.3毫克2,4-二氯苯氧基乙酸丁酯组中，磷脂显著减少。神经节苷脂增加，而胆固醇和糖脂减少；它们的减少与药物浓度呈反比。糖脂的减少表明正常髓鞘形成过程发生了改变。