Sanfilippo F, Shelburne J, Ingram P
Ultrastruct Pathol. 1980 Oct-Dec;1(4):471-5. doi: 10.3109/01913128009140553.
A 65-year-old female who received laryngeal injections with polytef (Teflon) paste for treatment of right vocal cord paralysis first noticed a small, right anterior neck mass 17 months later. Clinically this mass slowly progressed in size and was felt to be a recurrent carotid body tumor, but at surgery, 22 months after injection, a circumscribed nodule on the anterior right lobe of the thyroid was found and histologically diagnosed as a foreign body granuloma. Scanning electron microscopy (SEM) and energy-dispersive x-ray analysis (EDXA) of material in this lesion was identical to that of polytef paste, which is a mixture of pyrolyzed polytetrafluoroethylene and glycerine. The possibility that deaggregated smaller particles in the polytef paste were able to migrate from the injection site resulting in this neck mass is considered.
一名65岁女性因右侧声带麻痹接受聚四氟乙烯（特氟龙）糊剂喉部注射治疗，17个月后首次注意到右前颈部有一个小肿块。临床上，这个肿块大小缓慢增大，被认为是复发性颈动脉体瘤，但在注射后22个月手术时，发现甲状腺右叶前部有一个边界清楚的结节，组织学诊断为异物肉芽肿。对该病变中的物质进行扫描电子显微镜（SEM）和能量色散X射线分析（EDXA），结果与聚四氟乙烯糊剂相同，聚四氟乙烯糊剂是热解聚四氟乙烯和甘油的混合物。考虑了聚四氟乙烯糊剂中解聚的较小颗粒能够从注射部位迁移导致颈部肿块的可能性。
