Stephens C B, Arnold G E, Stone J W
Arch Otolaryngol. 1976 Jul;102(7):432-5. doi: 10.1001/archotol.1976.00780120080013.
A patient with inoperable lung cancer developed left-sided laryngeal paralysis. Her dysphonia, difficulty with swallowing, aspiration of secretions, and diminished cough reflex were improved with intracordal polytef injection for the remainder of her life. The foreign body reaction to the implant showed giant cells, few lymphocytes, and no polymorphonuclear leukocytes. This reaction may be described as a bland, chronic type consistent with the age of the implant. No areas of florid, acute reaction were found. Extrusion of part of the polytef through the cricothyroid space was observed. There were no signs of unfavorable tissue reaction, intolerance, or carcinogenicity. In a second case, part of the polytef paste exuded over the thyroid gland and was misinterpreted as a thyroid nodule. Excised 11 months after injection, the foreign body reaction appeared to be of a more acute type.
一名患有无法手术的肺癌患者出现了左侧喉麻痹。通过终生进行声带内聚四氟乙烯注射，她的声音嘶哑、吞咽困难、分泌物误吸和咳嗽反射减弱等症状得到了改善。对植入物的异物反应显示有巨细胞、少量淋巴细胞，无多形核白细胞。这种反应可描述为与植入物年龄相符的温和、慢性类型。未发现明显的急性反应区域。观察到部分聚四氟乙烯通过环甲间隙挤出。没有出现不良组织反应、不耐受或致癌性的迹象。在第二个病例中，部分聚四氟乙烯糊剂渗出到甲状腺上，被误诊为甲状腺结节。注射11个月后切除，异物反应似乎是更急性的类型。
