Adams G E, Stratford I J, Wallace R G, Wardman P, Watts M E
J Natl Cancer Inst. 1980 Mar;64(3):555-60.
Fifteen nitroaromatic and nitroheterocyclic compounds that can act as "radiosensitizers" were tested for their cytotoxicity toward hypoxic Chinese hamster V79 cells in vitro. The cytotoxicity increased markedly as the electron affinity, measured as a one-electron reduction potential, increased. Non-nitro-containing compounds of similar electron affinities (such as quinones) that also act as radiosensitizers did not exhibit this specific toxicity toward hypoxic cells. The implications of the presence of the nitro group as a prerequisite for the hypoxic cell toxicity were discussed, and the mechanism of the cytotoxicity was compared with that of hypoxic cell radiosensitization.
对15种可作为“放射增敏剂”的硝基芳香族和硝基杂环化合物进行了体外对缺氧中国仓鼠V79细胞的细胞毒性测试。随着以单电子还原电位衡量的电子亲和力增加，细胞毒性显著增强。具有类似电子亲和力的非含硝基化合物（如醌类）虽然也可作为放射增敏剂，但对缺氧细胞未表现出这种特异性毒性。讨论了硝基作为缺氧细胞毒性先决条件的意义，并将细胞毒性机制与缺氧细胞放射增敏机制进行了比较。
