Savi M, Asinari G, Gaudiano V, Neri T M
Minerva Med. 1978 Sep 15;69(42):2849-53.
Immunological disturbances in FMF have not been previously reported. In present case, positivity for RA and Waaler-Rose test as well as increase of plasma IgG and IgM immunoglobulins during an episode of acute peritonitis is described. These findings, in association with very high levels of urinary FDP, suggest an autoimmune pathogenesis of the disease.
此前尚未报道过家族性地中海热(FMF)中的免疫紊乱情况。在本病例中,描述了在急性腹膜炎发作期间类风湿因子(RA)和瓦勒 - 罗斯试验呈阳性,以及血浆免疫球蛋白IgG和IgM升高的情况。这些发现,再加上尿纤维蛋白降解产物(FDP)水平非常高,提示了该疾病的自身免疫发病机制。