Salmon D, Seger J, Salmon C
Am J Hum Genet. 1980 May;32(3):432-44.
The proportion of exclusion for a given mother-child pair is the proportion of males excluded from the paternity of this child of a known mother and may be calculated given both the child's and mother's phenotypes and the population gene frequencies. Its expected value in the population is equal to the probability of exclusion, which expresses a laboratory's capability to exclude from paternity nonbiological fathers.In a sample of 171 families examined for 20 genetic systems at the National Blood Group Reference Laboratory, 25 exclusions of putative fathers were detected. The ranking by efficiency of the systems used in these exclusions fits the "expectation of their efficiency," and the average proportion of males excluded by the child's and mother's phenotypes is not different from the expected proportion. Additionally, the repetition of exclusions in an incompatible putative father-mother-child trio is not dependent on the overall proportion of males excluded by the mother and the child, but rather on some high values of the proportion of excluded men in some specific systems.Here, formulas and some factors modifying these parameters as well as a more efficient sequence of examinations to exclude paternity than has previously been used are given. Using this sequence, laboratories which carry out several analyses per day can work by levels of five examinations at a time, done in a particular order, to obtain a rather rapid exclusion of certain families.
给定母子对的排除比例是指从已知母亲的孩子的父系中排除的男性比例，可根据孩子和母亲的表型以及群体基因频率来计算。其在群体中的期望值等于排除概率，该概率表示实验室从父系中排除非生物学父亲的能力。在国家血型参考实验室对171个家庭的20个遗传系统进行检测的样本中，检测到25例对推定父亲的排除。这些排除中所使用系统的效率排名符合“其效率预期”，并且孩子和母亲的表型所排除的男性平均比例与预期比例没有差异。此外，在不相容的推定父子三人组中排除情况的重复并不取决于母亲和孩子所排除男性的总体比例，而是取决于某些特定系统中排除男性比例的一些高值。在此，给出了公式以及一些修改这些参数的因素，还有一种比以前使用的更有效的排除父系的检测顺序。使用这个顺序，每天进行多次分析的实验室可以按特定顺序每次进行五级检测，从而相当迅速地排除某些家庭。
