Jung H, Beck H P, Brammer I, Zywietz F
Br J Cancer Suppl. 1980 Apr;4:226-9.
Rhabdomyosarcomas of the rat were irradiated with 15 Gy of X-rays and the changes in several parameters were measured as a function of time. In the course of 10 days after irradiation, the percentage of tumour cells changes by a factor of 10, the fraction of clonogenic cells by a factor of 20, and the volume of tumour cell nuclei by a factor of nearly 3. During the same time interval, tumour volume increases only by 50%, indicating that volume curves yield little information about the drastic changes occurring in tumours during the first 2 weeks after irradiation.
用15 Gy的X射线照射大鼠的横纹肌肉瘤，并测量几个参数随时间的变化。在照射后的10天内，肿瘤细胞百分比变化了10倍，克隆形成细胞分数变化了20倍，肿瘤细胞核体积变化了近3倍。在相同的时间间隔内，肿瘤体积仅增加了50%，这表明体积曲线几乎无法提供关于照射后前两周肿瘤内发生的剧烈变化的信息。
