Roberts-Thomson I C, Mitchell G F, Anders R F, Tait B D, Kerlin P, Kerr-Grant A, Cavanagh P
Gut. 1980 May;21(5):397-401. doi: 10.1136/gut.21.5.397.
Genetic markers were analysed in 48 adults who appeared to have a prolonged infection with Giardia lamblia. The frequency of ABO blood groups, Rhesus blood groups, and Gm phenotypes was similar to that in control subjects. However, there was a higher than expected frequency of HLA antigens A1 (observed 46 . 7%, expected 32%) and B12 (observed 47 . 8%, expected 25 . 8%) and a higher than expected frequency of the phenotypes A1/A2 and B12/B27. Genetic studies were also performed with inbred strains of mice showing relatively rapid (BALB/c) and defective (C3H/He) spontaneous elimination of Giardia muris. From analysis in backcross mice several genes appeared to influence susceptibility to prolonged infection with G. muris.
对48名似乎长期感染蓝氏贾第鞭毛虫的成年人进行了基因标记分析。ABO血型、恒河猴血型和Gm表型的频率与对照组相似。然而，HLA抗原A1（观察到的频率为46.7%，预期为32%）和B12（观察到的频率为47.8%，预期为25.8%）的频率高于预期，并且A1/A2和B12/B27表型的频率也高于预期。还对小鼠近交系进行了基因研究，这些近交系显示出对鼠贾第鞭毛虫的自发清除相对较快（BALB/c）和有缺陷（C3H/He）。通过对回交小鼠的分析，有几个基因似乎影响对鼠贾第鞭毛虫长期感染的易感性。
