人类和鼠类贾第虫病的遗传学研究。
Genetic studies in human and murine giardiasis.
作者信息
Roberts-Thomson I C, Mitchell G F, Anders R F, Tait B D, Kerlin P, Kerr-Grant A, Cavanagh P
出版信息
Gut. 1980 May;21(5):397-401. doi: 10.1136/gut.21.5.397.
Abstract
Genetic markers were analysed in 48 adults who appeared to have a prolonged infection with Giardia lamblia. The frequency of ABO blood groups, Rhesus blood groups, and Gm phenotypes was similar to that in control subjects. However, there was a higher than expected frequency of HLA antigens A1 (observed 46 . 7%, expected 32%) and B12 (observed 47 . 8%, expected 25 . 8%) and a higher than expected frequency of the phenotypes A1/A2 and B12/B27. Genetic studies were also performed with inbred strains of mice showing relatively rapid (BALB/c) and defective (C3H/He) spontaneous elimination of Giardia muris. From analysis in backcross mice several genes appeared to influence susceptibility to prolonged infection with G. muris.
摘要
对48名似乎长期感染蓝氏贾第鞭毛虫的成年人进行了基因标记分析。ABO血型、恒河猴血型和Gm表型的频率与对照组相似。然而，HLA抗原A1（观察到的频率为46.7%，预期为32%）和B12（观察到的频率为47.8%，预期为25.8%）的频率高于预期，并且A1/A2和B12/B27表型的频率也高于预期。还对小鼠近交系进行了基因研究，这些近交系显示出对鼠贾第鞭毛虫的自发清除相对较快（BALB/c）和有缺陷（C3H/He）。通过对回交小鼠的分析，有几个基因似乎影响对鼠贾第鞭毛虫长期感染的易感性。
相似文献
1
Genetic studies in human and murine giardiasis.人类和鼠类贾第虫病的遗传学研究。
Gut. 1980 May;21(5):397-401. doi: 10.1136/gut.21.5.397.
2
Genetic studies of human and murine giardiasis.人类和鼠类贾第虫病的遗传学研究。
Clin Infect Dis. 1993 Mar;16 Suppl 2:S98-104. doi: 10.1093/clinids/16.supplement_2.s98.
3
Protection of mice against Giardia muris infection.保护小鼠免受鼠贾第虫感染。
Infect Immun. 1979 Jun;24(3):971-3. doi: 10.1128/iai.24.3.971-973.1979.
4
An examination of differences in serum antibody specificities and hypersensitivity reactions as contributing factors to chronic infection with the intestinal protozoan parasite, Giardia muris, in mice.对血清抗体特异性差异和超敏反应作为小鼠肠道原生动物寄生虫鼠贾第虫慢性感染促成因素的研究。
Aust J Exp Biol Med Sci. 1983 Oct;61 ( Pt 5):599-615. doi: 10.1038/icb.1983.57.
5
Giardiasis in mice: analysis of humoral and cellular immune responses to Giardia muris.小鼠贾第虫病：对鼠贾第虫体液免疫和细胞免疫反应的分析
Parasite Immunol. 1982 Jan;4(1):47-57. doi: 10.1111/j.1365-3024.1982.tb00419.x.
6
Giardiasis in mice: studies on the characteristics of chronic infection in C3h/He mice.小鼠贾第虫病：C3h/He小鼠慢性感染特征的研究
J Immunol. 1981 Feb;126(2):669-72.
7
Susceptibility and resistance of inbred mice to Giardia muris.近交系小鼠对鼠贾第虫的易感性和抗性
Infect Immun. 1984 May;44(2):282-6. doi: 10.1128/iai.44.2.282-286.1984.
8
The relation between ABO blood groups, HLA typing and giardiasis in children.儿童ABO血型、人类白细胞抗原分型与贾第虫病之间的关系。
J Egypt Soc Parasitol. 1994 Aug;24(2):407-12.
9
ABO blood-group distribution and HLA typing in children with giardiasis.贾第虫病患儿的ABO血型分布及人类白细胞抗原分型
Trans R Soc Trop Med Hyg. 1990 May-Jun;84(3):380-1. doi: 10.1016/0035-9203(90)90326-a.
引用本文的文献
1
The course of experimental giardiasis in Mongolian gerbil.蒙古沙鼠实验性贾第虫病的病程
Parasitol Res. 2018 Aug;117(8):2437-2443. doi: 10.1007/s00436-018-5932-5. Epub 2018 May 24.
2
Ocular changes associated with Giardia lamblia infection in children.儿童贾第虫感染相关的眼部变化。
Br J Ophthalmol. 1998 Jan;82(1):59-62. doi: 10.1136/bjo.82.1.59.
3
Parasite immunity and the major histocompatibility complex.寄生虫免疫与主要组织相容性复合体
Immunogenetics. 1980;11(3):215-23. doi: 10.1007/BF01567789.
4
Susceptibility and resistance of inbred mice to Giardia muris.近交系小鼠对鼠贾第虫的易感性和抗性
Infect Immun. 1984 May;44(2):282-6. doi: 10.1128/iai.44.2.282-286.1984.
5
Giardiasis.贾第虫病
Indian J Pediatr. 1983 Jul-Aug;50(405):417-22. doi: 10.1007/BF02753384.
6
Changes in intestinal fluid and mucosal immune responses to cholera toxin in Giardia muris infection and binding of cholera toxin to Giardia muris trophozoites.微小隐孢子虫感染时肠道液体和对霍乱毒素的黏膜免疫反应的变化以及霍乱毒素与微小隐孢子虫滋养体的结合
Infect Immun. 1985 Oct;50(1):243-9. doi: 10.1128/iai.50.1.243-249.1985.
7
Susceptibility of domestic cats to infections with Giardia lamblia cysts and trophozoites from human sources.家猫对源自人类的蓝氏贾第鞭毛虫包囊和滋养体感染的易感性。
J Clin Microbiol. 1985 May;21(5):678-80. doi: 10.1128/jcm.21.5.678-680.1985.
8
An 88,000-Mr Giardia lamblia surface protein which is immunogenic in humans.一种分子量为88000的贾第虫表面蛋白，该蛋白对人类具有免疫原性。
Infect Immun. 1986 Dec;54(3):621-5. doi: 10.1128/iai.54.3.621-625.1986.
9
Giardiasis: analysis of histological changes in biopsy specimens of 80 patients.贾第虫病：80例患者活检标本的组织学变化分析
J Clin Pathol. 1990 Aug;43(8):641-3. doi: 10.1136/jcp.43.8.641.
10
From Leningrad to the day-care center. The ubiquitous Giardia lamblia.从列宁格勒到日托中心。无处不在的蓝氏贾第鞭毛虫。
West J Med. 1990 Aug;153(2):154-9.
本文引用的文献
1
EPITHELIAL AND OTHER MUCOSAL LESIONS OF THE JEJUNUM IN GIARDIASIS. JEJUNAL BIOPSY STUDIES.贾第虫病空肠的上皮及其他黏膜病变。空肠活检研究。
Bull Johns Hopkins Hosp. 1964 Nov;115:389-406.
2
Human infection with Giardia lamblia; an analysis of 32 cases.
Am J Dig Dis. 1958 Jan;3(1):64-71. doi: 10.1007/BF02231310.
3
The experimental transmission of human intestinal protozoan parasites. II. Giardia lamblia cysts given in capsules.人体肠道原生动物寄生虫的实验性传播。II. 以胶囊形式给予的蓝氏贾第鞭毛虫包囊。
Am J Hyg. 1954 Mar;59(2):209-20. doi: 10.1093/oxfordjournals.aje.a119634.
4
Interactive effect of Gm allotypes and HLA-B locus antigens on the human antibody response to a bacterial antigen.Gm 同种异型与 HLA - B 位点抗原对人体针对细菌抗原的抗体反应的交互作用。
Clin Exp Immunol. 1980 Apr;40(1):8-15.
5
Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test.同种移植的血清分型。18. 微滴淋巴细胞细胞毒性试验的改进。
Transplantation. 1968 Nov;6(8):913-27. doi: 10.1097/00007890-196811000-00006.
6
The effect of Giardia lamblia infestation on the gastro-intestinal tract.
Australas Ann Med. 1969 Aug;18(3):232-7. doi: 10.1111/imj.1969.18.3.232.
7
RElation of the human antibody response to flagellin to GM genotype.人类针对鞭毛蛋白的抗体反应与GM基因型的关系。
J Immunol. 1971 Dec;107(6):1505-11.
8
Studies of the regulatory effects of the sex hormones on antibody formation and stem cell differentiation.性激素对抗体形成和干细胞分化的调节作用研究。
J Exp Med. 1972 Nov 1;136(5):1098-116. doi: 10.1084/jem.136.5.1098.
9
HL-A antigens and disease. Statistical and genetical considerations.组织相容性白细胞抗原与疾病。统计学及遗传学考量。
Tissue Antigens. 1974;4(2):95-105. doi: 10.1111/j.1399-0039.1974.tb00230.x.
10
Giardiasis in the mouse: an animal model.小鼠贾第虫病：一种动物模型。
Gastroenterology. 1976 Jul;71(1):57-61.
Zotero 插件