Liebert M, Aster R H
Tissue Antigens. 1977 Apr;9(4):199-208. doi: 10.1111/j.1399-0039.1977.tb01108.x.
Expression of the antigen HLA-B12 on platelets, on lymphocytes and in serum of normal subjects was studied using several quantitative techniques. HLA-B12 was found to be expressed on platelets from each of 25 heterozygous HLA-B12-positive donors in amounts varying about 35-fold from weakest to strongest. Expression of B12 on platelets was enhanced in the presence of the first locus antigen A11, but decreased in the presence of A2, A3, and Aw28. The antigen was expressed in equal strength on lymphocytes sampled from the same donor population. Serum content of B12 assayed in five subjects was found to be roughly proportional to the expression of that antigen on platelets. Expression of B12 on platelets is under genetic control but the precise mechanism of inheritance has not yet been defined. The applicability of these findings to transfusion of single donor platelets to alloimmunized patients is under investigation.
运用多种定量技术，对正常受试者血小板、淋巴细胞及血清中抗原HLA - B12的表达情况进行了研究。发现来自25名杂合HLA - B12阳性供者的血小板均表达HLA - B12，表达量从最弱到最强相差约35倍。在第一个位点抗原A11存在时，血小板上B12的表达增强，但在A2、A3和Aw28存在时表达降低。从同一供者群体采集的淋巴细胞上该抗原表达强度相同。在5名受试者中检测的血清B12含量与该抗原在血小板上的表达大致成比例。血小板上B12的表达受遗传控制，但确切的遗传机制尚未明确。这些发现应用于向同种免疫患者输注单供者血小板的可行性正在研究中。
