一种与纯合细胞发生反应的“天然”抗HLA - A2抗体。
A "natural" anti-HLA-A2 antibody reacting with homozygous cells.
作者信息
Lepage V, Degos L, Dausset J
出版信息
Tissue Antigens. 1976 Aug;8(2):139-42.
PMID:968899
Abstract
In the serum of a young normal male, never transfused, a cold cytotoxic IgM antibody was found reacting exclusively with A2 homozygous cells on a French panel, as shown by population and family studies. This antibody needs about two to five times more lymphocytes or platelets to be absorbed than an immune anti-A2 of the same titre. The antigen recognized by this antibody seems to be covered by the same molecule as HLA-A2, according to redistribution experiments.
摘要
在一名从未接受过输血的年轻正常男性血清中，发现一种冷细胞毒性IgM抗体，群体和家族研究表明，该抗体仅与法国细胞面板上的纯合A2细胞发生反应。与相同滴度的免疫抗A2抗体相比，这种抗体吸收所需的淋巴细胞或血小板大约多两到五倍。根据再分布实验，这种抗体识别的抗原似乎与HLA - A2被同一分子覆盖。
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