Wyman J, Gill S J
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5239-42. doi: 10.1073/pnas.77.9.5239.
Polyphasic linkage is a close analog of the allosteric and polysteric linkages shown by many biological macromolecules. Like them, it gives rise to both homotropic and heterotropic effects. It is governed by a group of linkage potentials applicable to each separate phase and also, subject to certain conditions, by a group of lower order applicable to the whole system, globally. A good example of polyphasic linkage is provided by sickle cell hemoglobin which, under suitable conditions and subject to control by oxygen, precipitates out of solution to form what appear to be microtubules. This is but one instance of the way in which macromolecular assembly and the formation of subcellular structures generally can be regulated by various small molecules acting as ligands.
多相连接是许多生物大分子所表现出的别构和多聚体连接的紧密类似物。与它们一样，它会产生同促效应和异促效应。它由一组适用于每个单独相的连接电位控制，并且在某些条件下，也由一组适用于整个系统的低阶电位全局控制。镰状细胞血红蛋白就是多相连接的一个很好的例子，在合适的条件下并受氧气控制时，它会从溶液中沉淀出来，形成看似微管的结构。这只是大分子组装和亚细胞结构形成通常可由作为配体的各种小分子调节的方式之一。
