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T4重组缺陷型突变体等位基因间的表型差异。

Phenotypic differences among the alleles of the T4 recombination defective mutants.

作者信息

Melamede R J, Wallace S S

出版信息

Mol Gen Genet. 1980;179(2):327-30. doi: 10.1007/BF00425460.

Abstract

The allelic forms of the phage genes T4 chi and fdsA, as well as T4y and fdsB are compared in terms of their thymidine incorporation in high or low concentrations of thymidine, sensitivity of DNA synthetic capacity to mitomycin C, and sedimentation rates of DNA replicative intermediates. The results show differences among these mutants for the incorporation of thymidine; however all exhibit mitomycin C-sensitive DNA synthesis and have identical aberrant sedimentation rates for their DNA replicative intermediates.

摘要

对噬菌体基因T4 chi和fdsA以及T4y和fdsB的等位基因形式,就其在高浓度或低浓度胸苷中的胸苷掺入情况、DNA合成能力对丝裂霉素C的敏感性以及DNA复制中间体的沉降速率进行了比较。结果显示这些突变体在胸苷掺入方面存在差异;然而,所有突变体都表现出对丝裂霉素C敏感的DNA合成,并且其DNA复制中间体具有相同的异常沉降速率。

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