噬菌体T4中的脱氧核糖核酸修复：关于x和v基因以及宿主因子作用的观察
Deoxyribonucleic acid repair in bacteriophage T4: observations on the roles of the x and v genes and of host factors.
作者信息
Mortelmans K, Friedberg E C
出版信息
J Virol. 1972 Oct;10(4):730-6. doi: 10.1128/JVI.10.4.730-736.1972.
Abstract
Studies were carried out to determine the effect of mutation in the host pol I gene on survival of ultraviolet (UV)-irradiated bacteriophage T4. Whereas a slightly reduced survival was observed in Escherichia coli strain P-3478 (pol A(1)) compared to strain W-3110 (pol A(+)), no such difference was observed in two strains isogenic except for the pol A gene. It was also shown that, whereas bacteriophage T4x is sensitive to UV irradiation, X irradiation, and treatment with methyl-methanesulfonate (MMS), phage T4v(1) is sensitive only to UV irradiation. The survival of damaged phage T4x is neither affected by the presence of the rec A, rec B, or pol A mutations in the host, nor is there evidence that phage T4 effects repair of rec A or pol A mutants previously treated with either UV or MMS.
摘要
开展了多项研究以确定宿主聚合酶I基因的突变对紫外线（UV）照射的噬菌体T4存活的影响。与W-3110菌株（pol A(+)）相比，在大肠杆菌P-3478菌株（pol A(1)）中观察到存活率略有降低，但在除pol A基因外其他基因均相同的两个菌株中未观察到此类差异。还表明，噬菌体T4x对UV照射、X射线照射及甲磺酸甲酯（MMS）处理敏感，而噬菌体T4v(1)仅对UV照射敏感。受损噬菌体T4x的存活既不受宿主中rec A、rec B或pol A突变的影响，也没有证据表明噬菌体T4能修复先前经UV或MMS处理的rec A或pol A突变体。
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