成年大鼠肝上皮细胞中次黄嘌呤磷酸核糖基转移酶基因座的细胞周期特异性诱变
Cell cycle-specific mutagenesis at the hypoxanthine phosphoribosyltransferase locus in adult rat liver epithelial cells.
作者信息
Tong C, Fazio M, Williams G M
出版信息
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7377-9. doi: 10.1073/pnas.77.12.7377.
Abstract
The cell cycle specificity of chemical mutagenesis was studied by use of two cell synchronization techniques, one a nontoxic technique involving serum deprivation and the other a double thymidine block, to obtain rat liver epithelial cells in different phases of the cell cycle to be exposed to chemical mutagens. For both methyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine, there was a cell cycle specificity of chemical mutagenesis, with the most sensitive phase being the period of DNA synthesis.
摘要
利用两种细胞同步化技术研究了化学诱变的细胞周期特异性，一种是涉及血清剥夺的无毒技术，另一种是双胸腺嘧啶核苷阻断法，以获得处于细胞周期不同阶段的大鼠肝上皮细胞，使其暴露于化学诱变剂中。对于甲磺酸甲酯和N-甲基-N'-硝基-N-亚硝基胍而言，化学诱变均具有细胞周期特异性，最敏感的阶段是DNA合成期。
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