Walshe J M
J Rheumatol Suppl. 1981 Jan-Feb;7:155-60.
Penicillamine-induced systemic lupus erythematosus (SLE) and penicillamine-immune complex nephritis are histologically and serologically distinct. One hundred and twenty patients with Wilson's disease treated with penicillamine have been analyzed. Eight developed the serologic changes of SLE; in 4, it was necessary to discontinue treatment. In addition, 6 patients developed immune complex nephritis, which necessitated discontinuing treatment. All but 1 have since been managed on triethylene tetramine 2HCl (Trien).
青霉胺诱发的系统性红斑狼疮（SLE）和青霉胺免疫复合物肾炎在组织学和血清学上是不同的。对120例接受青霉胺治疗的威尔逊病患者进行了分析。8例出现了SLE的血清学改变；其中4例需要停止治疗。此外，6例患者发生了免疫复合物肾炎，这也需要停止治疗。除1例患者外，其余所有患者此后均采用二盐酸三亚乙基四胺（Trien）进行治疗。
