年龄对淋巴细胞中胱硫醚合酶、尿卟啉原I合酶和葡萄糖-6-磷酸脱氢酶活性诱导的影响。
Effect of chronologic age on induction of cystathionine synthase, uroporphyrinogen I synthase, and glucose-6-phosphate dehydrogenase activities in lymphocytes.
作者信息
Gartler S M, Hornung S K, Motulsky A G
出版信息
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1916-9. doi: 10.1073/pnas.78.3.1916.
The activities of cystathionine synthase [L-serine hydro-lyase (adding homocysteine), EC 4.2.1.22], uroporphyrinogen I synthase [porphobilinogen ammonia-lyase (polymerizing), EC 4.3.1.8], and glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate:NADP+ 1-oxidoreductase, EC 1.1.1.49) have been measured in phytohemagglutinin-stimulated lymphocytes of young and old human subjects. A significant decrease in activity with age was observed for cystathionine synthase and uroporphyrinogen I synthase but not for glucose-6-phosphate dehydrogenase. These changes could not be related to declining phytohemagglutinin response with aging. Age-related decreases in activity of some enzymes may be relevant for an understanding of the biology of aging. False assignment of heterozygosity, and even homozygosity, for certain genetic disorders, such as homocystinuria, may result when low enzyme levels are detected in the lymphocytes of older people.
在年轻和老年受试者经植物血凝素刺激的淋巴细胞中，已对胱硫醚合酶[L-丝氨酸水解酶（添加高半胱氨酸），EC 4.2.1.22]、尿卟啉原I合酶[胆色素原氨裂解酶（聚合），EC 4.3.1.8]以及葡萄糖-6-磷酸脱氢酶（D-葡萄糖-6-磷酸：NADP + 1-氧化还原酶，EC 1.1.1.49）的活性进行了测定。观察到胱硫醚合酶和尿卟啉原I合酶的活性随年龄增长显著下降，但葡萄糖-6-磷酸脱氢酶的活性未下降。这些变化与衰老过程中植物血凝素反应的下降无关。某些酶活性的年龄相关性下降可能与理解衰老生物学有关。当在老年人的淋巴细胞中检测到低酶水平时，可能会导致对某些遗传疾病，如高胱氨酸尿症，错误地判定为杂合性，甚至纯合性。
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