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老年人淋巴细胞功能受损。

Impaired lymphocyte function in aged humans.

作者信息

Weksler M E, Hütteroth T H

出版信息

J Clin Invest. 1974 Jan;53(1):99-104. doi: 10.1172/JCI107565.

DOI:10.1172/JCI107565
PMID:4855547
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC301443/
Abstract

The response of lymphocytes from young and old persons to phytohemagglutinin, pokeweed mitogen, or allogeneic lymphocytes has been measured. Lymphocytes from old persons incorporated significantly less tritiated thymidine as compared with lymphocytes from young persons when cultured with plant mitogens or allogeneic cells. The difference in observed lymphocyte reactivity could not be attributed to differences in culture conditions required for maximal transformation of lymphocytes from old or young subjects. The same percentage of thymus-derived and bone marrow-derived lymphocytes was found in the blood from old and young persons. The relationship of these findings to the decline of immunologic competence with age is discussed.

摘要

已对年轻人和老年人的淋巴细胞对植物血凝素、商陆有丝分裂原或同种异体淋巴细胞的反应进行了测定。与年轻人的淋巴细胞相比，老年人的淋巴细胞在与植物有丝分裂原或同种异体细胞一起培养时，掺入的氚标记胸腺嘧啶核苷明显较少。观察到的淋巴细胞反应性差异不能归因于使老年人或年轻人的淋巴细胞实现最大转化所需的培养条件差异。在老年人和年轻人的血液中发现胸腺来源和骨髓来源的淋巴细胞比例相同。讨论了这些发现与免疫能力随年龄下降的关系。

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本文引用的文献

1
Hematologic values in the aged.老年人的血液学指标
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Mitogenic effect of phytohaemagglutinin at different ages.不同年龄段植物血凝素的促有丝分裂作用。
Nature. 1967 Jul 8;215(5097):193-4. doi: 10.1038/215193a0.
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Age-dependent tumor-host barrier and effect of carcinogen-induced immunodepression on rejection of isografted methylcholanthrene-induced sarcoma cells.年龄依赖性肿瘤-宿主屏障以及致癌物诱导的免疫抑制对同基因移植的甲基胆蒽诱导肉瘤细胞排斥反应的影响。
J Natl Cancer Inst. 1966 Oct;37(4):505-12.
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Selective service and military medical manpower.义务兵役制与军事医疗人力
JAMA. 1968 Jan 8;203(2):111-2.
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